Antimicrobial Agents and Chemotherapy

In vitro Evaluation of Methylxanthines and Some Antibiotics: Interaction against Staphylococcus aureus and Pseudomonas aeruginosa

Background: The development of resistance to antimicrobial agents is a major problem in chemotherapy. Finding agents which potentiate antimicrobial activity could be favorable. There are some reports that methylxanthines changed the inhibitory effect of antibacterial agents. Thus, possible synergistic effect of methylxanthines, aminophylline and caffeine on some antibiotics, carbenicillin, ceft...

Genetic methods for assessing antimicrobial resistance.

Tn916 family conjugative transposons and dissemination of antimicrobial resistance determinants.

Susceptibility of Clostridium septicum to 23 antimicrobial agents.

The in vitro susceptibility of Clostridium septicum was studied with a microtiter broth dilution method. Several antimicrobial agents demonstrated consistently good activity against the organism.

Yersinia enterocolitica: in vitro antimicrobial susceptibility.

Using 21 antimicrobial agents, agar dilution susceptibility tests were carried out against 190 strains of Yersinia enterocolitica. Isolates from human, environmental, and animal sources had essentially equal susceptibility patterns.

Corynebacterium equi: in vitro susceptibility to twenty-six antimicrobial agents.

The minimal concentrations of 26 antimicrobial agents required to inhibit growth of 100 isolates of Corynebacterium equi in vitro have been determined. The most active agents were penicillin G, doxycycline, erythromycin, lincomycin, and the aminoglycosides.